Title
Mn(II) silver-aptamer clusters for target MR image of tumor
Author
Wei-Yu Mu, Xin-Xin Xiao, Tian-Tian Chen, Qiu-Yun Chen
Year
2016
Journal
Journal of Materials Chemistry B
Abstract
Hypoxia-inducible factor (HIF) is highly expressed in most of cancer cell. The Mn(II)-aptamer based nanoclusters with 3D structures would be HIF-aptamer based target magnetic resonance image agents for cancer MRI diagnosis. Herein, a new type of contrast agent Mn(II) silver-aptamer clusters (AdpaMn@DNA-Ag-DNAG1) were constructed based on the assembly of DNA-mediated Ag nanoclusters (DNA-AgNCs) with the Mn(II) complex (AdpaMn) and DNAG1, the recognition sequence of GLUT-1. Then, the Mn(II) silver-aptamer clusters (AdpaMn@DNA-Ag-DNAG1) is used as the MRI agents both in vitro and in vivo. The results show that the MRI signal is highly presented in tumor position. Consequently, the Mn(II) silver-aptamer clusters can be used as a new kind of contrast agent for target MR image of tumor.
Instrument
J-815
Keywords
Circular dichroism, DNA structure, Nanostructures, Materials, Biochemistry