Title
Modular synthesis of supramolecular DNA amphiphiles through host–guest interactions and their self-assembly into DNA-decorated nanovesicles
Author
Shine K. Albert, Hari Veera Prasad Thelu, Murali Golla, Nithiyanandan Krishnan, Reji Varghese
Year
2017
Journal
Nanoscale
Abstract
DNA nanostructures have found potential applications in various fields including nanotechnology, materials science and nanomedicine, hence the design and synthesis of DNA nanostructures is extremely important. Self-assembly of DNA amphiphiles provides an efficient strategy for the crafting of soft DNA nanostructures. However, the synthesis of DNA amphiphiles is always challenging. Herein, we show a non-covalent approach based on the host–guest interaction between β-CD and adamantane for the synthesis of DNA amphiphiles, and report their amphiphilicity-driven self-assembly into DNA decorated vesicles. The DNA-directed surface addressability of the vesicles is demonstrated through their surface decoration with Au-NPs through DNA hybridization. Our results suggest that the non-covalent approach represents a simple, efficient and universal method for the synthesis of DNA amphiphiles, and provides an excellent strategy for the creation of smart DNA nanostructures.
Instrument
J-815
Keywords
Circular dichroism, DNA structure, Biochemistry