Title
Neuroprotective constituents from the fruits of Maclura tricuspidata
Author
Nguyen Tuan Hiep, Jaeyoung Kwon, Dong-Woo Kim, Sungeun Hong, Yuanqiang Guo, Bang Yeon Hwang, Nahyun Kim, Woongchon Mar, Dongho Lee
Year
2017
Journal
Tetrahedron
Abstract
Cudraisoflavone L − T (1–11), cudrahidrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5–18.6 μM. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5–11.9 μM.
Instrument
J-1100
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical