New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.

By Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Xingzhong Liu, Jian Zou, Guodong Chen, Li Li, Ling Liu

July 28, 2017

  • Year

  • Technique

  • Industry

Title

New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.

Author

Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Xingzhong Liu, Jian Zou, Guodong Chen, Li Li, Ling Liu

Year

2016

Journal

RSC Advances

Abstract

Five new cadinane sesquiterpenoids, pholiotins A–E (1–5), and three known compounds, 11-hydroxy-1(10)-valencen-2-one (6), 8,11-dihydroxy-1(10)-eremophilen-2-one (7) and durgamone (8), were isolated from the crude extract of Pholiota sp. Their structures were established on the basis of extensive spectroscopic analysis. Their absolute configurations were determined by X-ray diffraction, the Snatzke's method and electronic circular dichroism (ECD) calculations. All isolates were tested for antifungal activity.

Full Article

http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra22448b

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal