Title
New potently bioactive alkaloids from Crinum erubescens
Author
Christopher C. Presley, Priscilla Krai, Seema Dalal, Qingxi Su, Maria Cassera, Michael Goetz, David G.I. Kingston
Year
2016
Journal
Bioorganic & Medicinal Chemistry
Abstract
Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2were determined from their spectroscopic data to be the known pesticidal compound cripowellin A and the known pesticidal and antiproliferative compound cripowellin B. 1D and 2D-NMR techniques were used to determine the identities of 3 and 4 as the new compounds cripowellin C and D. A fifth compound was identified as the known alkaloid hippadine, which was inactive against Plasmodium falciparum. The antiplasmodial IC50values of compounds 1–4 were determined to be 30 ± 2, 180 ± 20, 26 ± 2, and 260 ± 20 nM, respectively, and their antiproliferative IC50 values against the A2780 human ovarian cancer cell line were 11.1 ± 0.4, 16.4 ± 0.1, 25 ± 2, and 28 ± 1 nM.
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Natural products, Medicinal