New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B
Qiao-Qiao Tao, Ke Ma, Li Bao, Kai Wang, Jun-Jie Han, Jin-Xia Zhang, Chen-Yang Huang, Hong-Wei Liu
Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G–O (1–9) and three known sesquiterpenoids, clitocybulols C–E (10 − 12), were isolated from the solid culture of the edible fungus Pleurotus cystidiosus. The structures of compounds 1–12 were determined by spectroscopic methods. The absolute configurations of compounds 1–9were assigned via the circular dichroism (CD) data analysis. Compounds 1, 6 and 10showed moderate inhibitory activity against protein tyrosine phosphatase-1B (PTP1B) with IC50 values of 49.5, 38.1 and 36.0 μM, respectively.
Circular dichroism, Absolute configuration, Medicinal, Agricultural and environmental