Title
New Spiral γ-Lactone Enantiomers from the Plant Endophytic FungusPestalotiopsis foedan
Author
Xiao-Long Yang, Zhuang-Zhuang Li
Year
2013
Journal
Molecules
Abstract
(−)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1bshowed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines.
Full Article
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical