New streptophenazines from marineStreptomyces sp. 182SMLY
Ying Liang, Lu Chen, Xuewei Ye, Komal Anjum, Xiao-Yuan Lian, Zhizhen Zhanga
Natural Product Research
Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M–O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureuswith MIC value of 4.2 μg/mL.
Circular dichroism, Absolute configuration, Pharmaceutical