Title
NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum
Author
Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Dihua Li, Chunyan Wang, Dongho Lee, Jing Xu, Ling Shuai, Jin Jin, Yuanqiang Guo
Year
2019
Journal
Bioorganic Chemistry
Abstract
Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3–5), and seven known analogues (6–12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
Instrument
J-715
Keywords
Circular dichroism, Stereochemistry, Absolute configuration, Natural products, Biochemistry, Medicinal