Title
One pot synthesis of structurally different mono and dimeric Ni(II) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study
Author
R. Prabhakaran, P. Kalaivani, P. Poornima, F. Dallemer, G. Paramaguru, V. Vijaya Padma, R. Renganathan, R. Huang, K. Natarajan
Year
2012
Journal
Dalton Transactions
Abstract
One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3were obtained from the reaction between [NiCl2(PPh3)2], 1,2-bis(diphenylphosphino)ethane, and [H2-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh3)] (1) and [(Ni(Sal-tsc))2(μ-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions.
Instrument
FP-6600
Keywords
Fluorescence, DNA structure, Ligand binding, Protein structure, Coordination chemistry, Biochemistry