Title
Pepsin Digest of Gliadin Forms Spontaneously Amyloid-Like Nanostructures Influencing the Expression of Selected Pro-Inflammatory, Chemoattractant, and Apoptotic Genes in Caco-2 Cells: Implications for Gluten-Related Disorders
Author
Maria Georgina Herrera, Francesco Nicoletti, Masion Gras, Philippo W. Dorfler, Nicolo Tonali, Yvonne Hannappel, Inga Ennen Andreas Hutten, Thomas Hellweg, Karen M. Lammers, Veronica I. Dodero
Year
2021
Journal
Molecular Nutrition Food Research
Abstract
Proteolysis-resistant gliadin peptides are intensely investigated in biomedical research relates to celiac disease and gluten-related disorders. Herein, the first integrated supramolecular investigation of pepsin-digested gliadin peptides (p-gliadin) is presented in combination with its functional behavior in the Caco-2 cell line.
Instrument
J-810
Keywords
peptides, biomedical, celiac disease