Title
Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis
Author
Kalkena Sivanesam, Irene Shu, Kelly N. L. Huggins, Marianna Tatarek-Nossol, Aphrodite Kapurniotu, Niels H. Andersen
Year
2016
Journal
FEBS Letters
Abstract
Versions of a previously discovered β-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed.
Instrument
J-720
Keywords
Circular dichroism, Secondary structure, Thermal stability, Aggregation, Biochemistry