Title
Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani
Author
Natsuki Tanokashira, Sanako Kukita, Hikaru Kato, Tatsuo Nehira, Esther D. Angkouw, Remy E.P. Mangindaan, Nicole J. de Voogd, Sachiko Tsukamoto
Year
2016
Journal
Tetrahedron
Abstract
We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with IC50 values in the range of 0.13–2.0 μM.
Instrument
J-820
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical