Title
Phosphorus(V) Corrole: DNA Binding, Photonuclease Activity and Cytotoxicity toward Tumor Cells
Author
Yi-Guang Wang, Zhao Zhang, Hui Wang, Hai-Yang Liu
Year
2016
Journal
Bioorganic Chemistry
Abstract
A new phosphorus(V) corrole, 10-(4-hydroxylphenyl)-5,15-bis(pentafluorophenyl)corrolato (trans-dihydroxo)phosphorus(V) 1-P, was synthesized and characterized. The interaction of 1-P and calf thymus DNA (CT-DNA) was studied by multi-spectroscopic methods. The photonuclease activity of this complex was examined by agarose gel electrophoresis. 1-P may bind to CT-DNA via an outside binding mode and display good photonuclease activity. 1-P displayed low dark toxicity but high photocytotoxic activity against H460 and A549 tumor cell lines.
Instrument
J-810
Keywords
Circular dichroism, DNA structure, Biochemistry