Title
Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin
Author
Huan Zhu, Qin-Mei Zhou, Cheng Peng, Ming-Hua Chen, Xiao-Nian Li, Da-Sheng Lin, Liang Xiong
Year
2017
Journal
Fitoterapia
Abstract
Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 μM.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal, Pharmaceutical