Prenylated benzophenone derivatives from Hypericum patulum

By Naonobu Tanaka, Kanji Niwa, Yuki Yano, Yoshiki Kashiwada

November 13, 2019

  • Year

  • Technique

  • Industry

Title

Prenylated benzophenone derivatives from Hypericum patulum

Author

Naonobu Tanaka, Kanji Niwa, Yuki Yano, Yoshiki Kashiwada

Year

2019

Journal

Journal of Natural Medicines

Abstract

A new prenylated benzophenone, hypatulin C (1), was isolated from the leaves of Hypericum patulum together with a biogenetically related analog, hypelodin B (2). Hypatulin C (1) had a tricyclic [4.3.1.03,7]-decane moiety substituted by four prenyl groups. The structure of 1 was elucidated by detailed spectroscopic analyses, while the absolute stereochemistries of 1 and 2 were assigned by comparison of their ECD spectra with TDDFT calculated spectra.

Full Article

https://link.springer.com/article/10.1007/s11418-019-01350-3

Instrument

J-1500

Keywords

Circular dichroism, Stereochemistry, Absolute configuration, Medicinal, Natural products