Preparation of Phosphorescent Eu2+, Dy3+-Doped Strontium Aluminate Nanoparticles by Laser Vaporization for the Modification of Therapeutic Contact Lenses
Jan Häusler, Frank A. Müller, Lenka Müller, Janet Grabow, Carla Cleve, Christian Lotz, Mona Röschlau, Patrick Bittorf, Roland Fromme, Ingrid Kiebert, Michelle Grüne, Stefan Schweizer, Sofia Dembski
Advanced Photonics Research
Biologically, effectively regulated light with a wavelength of about 485 nm can support physiological processes in the body and has a positive impact on the human sleep–wake rhythm. However, the application of common light therapy devices is not always practicable and sometimes difficult to integrate into everyday life. Here, miniaturization of therapy devices, for example, in the form of contact lenses, can reduce the handling disadvantages. Especially, contact lenses modified with phosphorescence materials offer this benefit. Herein, a method to prepare phosphorescent Eu2+, Dy3+-doped strontium aluminate nanoparticles (NPs) by laser vaporization of macroscopic Eu2+, Dy3+-doped Sr4Al14O25 particle powder and their integration into polymer-based contact lenses is provided. NPs with a diameter of about 34 nm emit light in the desired therapeutic wavelength region. These novel NPs are biocompatible and do not show any negative effects during the testing of eye irritation safety in a 3D in vitro cornea model.
nanoparticles, NPs, therapy, device, sleep