Pterocaullins A−D, four sesquiterpene lactones from Inula pterocaula

November 13, 2019

Title

Pterocaullins A−D, four sesquiterpene lactones from Inula pterocaula

Author

Sheng-Lan Zhu, Chun-Li Huang, Yong-Zhen Xiao, Yang-Guo Xie, Guo-Jing Wu, Wei-Dong Zhang, Yan Zhang, Dai-Jie Chen, Hui-Zi Jin

Year

2019

Journal

Phytochemistry Letters

Abstract

Four new sesquiterpenes, pterocaullins A−D (1−4), along with ten known compounds were isolated from the whole plants of Inula pterocaula. Structures of new compounds were elucidated by the combined use of HRESIMS, 1D and 2D NMR and CD spectroscopic methods. The absolute structures of 1 and 2 were further confirmed by Cu Kα X-ray crystallographic analyses. In addition, all isolated compounds were tested for their inhibitory effects against LPS-induced NO production in RAW 264.7 macrophages. Pterocaullin B displayed potential anti-inflammatory activity with IC50 value of 7.03 μM.

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Pharmaceutical