Title
Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA
Author
Soyoung Chang, Tugba Kilic, Chang Kee Lee, Huseyin Avci, Hojae Bae, Shirin Mesbah Oskui, Sung Mi Jung, Su Ryon Shin, Seon Jeong Kim
Year
2018
Journal
Nanomaterials
Abstract
The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors.
Full Article
Instrument
J-810
Keywords
Circular dichroism, DNA structure, Chemical stability, Biochemistry