Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

By Mohamed-Elamir F. Hegazy, Tarik A. Mohamed, Abdelsamed I. Elshamy, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta, Akemi Umeyama, Paul W. Paré, Thomas Efferth

November 13, 2019

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Title

Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Author

Mohamed-Elamir F. Hegazy, Tarik A. Mohamed, Abdelsamed I. Elshamy, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta, Akemi Umeyama, Paul W. Paré, Thomas Efferth

Year

2019

Journal

RSC Advances

Abstract

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).

Full Article

https://pubs.rsc.org/en/content/articlehtml/2019/ra/c9ra04158c

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Natural products, Biochemistry, Medicinal