Title
Sesquiterpene dimers from the roots of Chloranthus holostegius with moderate anti-inflammatory activity
Author
Chuan-Pu Shen, Jian-Guang Luo, , Ming-Hua Yang, Ling-Yi Kong
Year
2017
Journal
Phytochemistry
Abstract
Eight lindenane dimers, chololactones A-H, along with two known compounds, were isolated from the roots of Chloranthus holostegius. Their structures were elucidated using 1D/2D NMR and HRESIMS, and their absolute configurations were determined using the ECD exciton chirality method. All isolates were tested for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW 264.7 macrophages, and showed moderate activity with IC50 values at 3.5–35.4 μM.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal