Title
Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation
Author
Hyun-Jae Jang, Jin-Han Kim, Hyun-Mee Oh, Min-Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young-Ho Kim, Woo Song Lee, Seung Woong Lee, Mun-Chual Rho
Year
2016
Journal
Chemical and Pharmaceutical Bulletin
Abstract
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract ofCurcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
Instrument
J-710
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical