Title
Split-Ugi Reaction with Chiral Compounds: Synthesis of Piperazine- and Bispidine-Based Peptidomimetics
Author
Mattia Stucchi, Giordano Lesma
Year
2016
Journal
Helvetica Chimica Acta
Abstract
A simple, one-step, stereoconservative synthesis of diamine-based peptidomimetics is described, by split-Ugi multicomponent reaction, involving chiral N-protected amino acids and α-substituted isocyanoacetate. In particular, piperazine and bispidine (3,7-diazabicyclo[3.3.1]nonane) are exploited as diamine components, bispidine being the first example of a sterically demanding bicyclic system employed in a split-Ugi reaction.
Instrument
J-715
Keywords
Circular dichroism, Absolute configuration