Title
Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs
Author
Simina Dreve, Iren Kacso, Adriana Popa, Oana Raita, Felicia Dragan, A. Bende, Gh. Borodi, I. Bratu
Year
2011
Journal
Journal of Molecular Structure
Abstract
The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08 mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze–drying at −60 °C and 0.009 atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular cross-linked assemblies
Instrument
IRT-3000
Keywords
FTIR microscopy, Chitosan, Microspheres, Anti-inflammatory drugs, Molecular spectroscopy