Title
Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives
Author
E. A. Popova, O. V. Mikolaichuk, A. V. Protas, A. V. Mukhametshina, G. K. Ovsepyan, G. L. Starova R. V. Suezov, A. V. Fonin, R. E. Trifonov
Year
2018
Journal
Russian Journal of General Chemistry
Abstract
A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.
Instrument
J-810
Keywords
Circular dichroism, DNA structure, Ligand binding, Inorganic chemistry, Biochemistry