Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

By Sengan Megarajan, Siva Bala Subramaniyan, Sureshan Muthuswamy, Savarimuthu Philip Anthony, Jothi Arunachalam, Dohyun Moon, Anbazhagan Veerappan

October 11, 2018

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Title

Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

Author

Sengan Megarajan, Siva Bala Subramaniyan, Sureshan Muthuswamy, Savarimuthu Philip Anthony, Jothi Arunachalam, Dohyun Moon, Anbazhagan Veerappan

Year

2018

Journal

RSC Advances

Abstract

Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B.

Full Article

https://pubs.rsc.org/en/content/articlehtml/2018/ra/c8ra06479b

Instrument

FP-8200

Keywords

Fluorescence, Quantitation, Membrane structure, Thermal stability, Chemical stability, Biochemistry, Materials