2021 / Nature Communications
Furanosteroids, represented by wortmannin, viridin, and demethoxyviridin, are a special group of fungal-derived, highly oxygenated steroids featured by an extra… Continue reading Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
2021 / Scientific Report
The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated… Continue reading Periplocin and cardiac glycosides suppress the unfolded protein response
2021 / Nature Communications
A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities… Continue reading Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
2021 / Journal of Asian Natural Products Research
Phytochemical investigation on the 80% EtOH extract of the whole plants of Zephyranthes grandiflora afforded three new 4a-epi-plicamine-type alkaloids, zephyranthines… Continue reading Cytotoxic plicamine alkaloids from the whole plants of Zephyranthes grandiflora
2021 / Fitoterapia
Four new lignans, patulinones A−D (1–4) and three new acetophenone derivatives, patulinones E−G (5–7) were isolated from the leaves of… Continue reading New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia
2021 / Marine Drugs
Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated… Continue reading New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2
2021 / Fitoterapia
Four new lignans, patulinones A−D (1–4) and three new acetophenone derivatives, patulinones E−G (5–7) were isolated from the leaves of… Continue reading New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia
2020 / Chinese Herbal Medicines Volume 12, Issue 3, July 2020, Pages 342-346
Objective To isolate the phenolic compounds obtained from the dried roots of Polygonum multiflorum and investigate their pharmacological activities. Methods… Continue reading New phenolic constituents obtained from Polygonum multiflorum
2018 / Scientific Reports volume 8, Article number: 4433 (2018)
Over 12% of the world’s health resources are spent on treating diabetes, as high blood glucose is the third cause… Continue reading Size Exclusion Chromatography Method for Purification of Nicotinamide Mononucleotide (NMN) from Bacterial Cells
2020 / Scientific Reports volume 10, Article number: 13621 (2020)
Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5′-phosphate oxidase deficiency (PNPOD; OMIM: 610090),… Continue reading Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy
2020 / Scientific Reports volume 10, Article number: 13721 (2020)
Colorectal cancer is the most common type of gastrointestinal cancers with poor survival and limited therapeutic options. In this study,… Continue reading Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum
2020 / Biointerface Research in Applied Chemistry, Research Articale Volume 10, Issue 5, 2020, 6550 - 6564
Syzygium cumini (L.) Skeels (or Eugenia jambolana) is a species that belongs to the Myrtaceae family been used empirically to… Continue reading Total Synthetic Development and Pharmacological Screening of Bioactive Isolated from Syzygium cuminii (l) Skeel
