To investigate the class-dependent properties of anti-viral IgM antibodies, we use membrane antigen capture activated cell sorting to isolate spike-protein-specific …
Continue reading “Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch”
Carlos Morillo
May 16, 2022
Trait expression of natural populations often jointly depends on prevailing abiotic environmental conditions and predation risk. Copepods, for example, can …
Continue reading “The influence of predator community composition on photoprotective traits of copepods”
Carlos Morillo
May 16, 2022
Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as …
Continue reading “Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs”
Carlos Morillo
May 16, 2022
Bio-based 5-hydroxymethylfurfural (HMF) serves as an important platform for several chemicals, among which 2,5-furan dicarboxylic acid (FDCA) has attracted considerable …
Continue reading “Oxidation of 5-hydroxymethylfurfural with a novel aryl alcohol oxidase from Mycobacterium sp. MS1601”
Carlos Morillo
April 18, 2022
Carlos Morillo
April 18, 2022
Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical …
Continue reading “The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation”
Carlos Morillo
February 24, 2022
Stereolithography is a lithography-based additive manufacturing technology, in which liquid photoreactive resins are solidified by ultraviolet or visible light in …
Continue reading “Novel Thiol-Ene Photo Resins for Stereolithography with Enhanced Mechanical and Optical Properties”
Carlos Morillo
February 24, 2022
The conserved ATPase p97 (Cdc48 in yeast) and adaptors mediate diverse cellular processes through unfolding polyubiquitinated proteins and extracting them …
Continue reading “Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state”
Carlos Morillo
February 24, 2022
Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO), formed from metaorganismal metabolism …
Continue reading “Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation”
Carlos Morillo
February 1, 2022
Extracellular vesicles (EVs) are released during the storage of red blood cell (RBC) concentrates and might play adverse or beneficial …
Continue reading “Storage conditions determine the characteristics of red blood cell derived extracellular vesicles”
Carlos Morillo
February 1, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques …
Continue reading “Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice”
Carlos Morillo
February 1, 2022
Tissue reconstruction has an unmet need for soft active scaffolds that enable gentle loading with regeneration-directing bioactive components by soaking …
Continue reading “An Inverse Shape-Memory Hydrogel Scaffold Switching Upon Cooling in a Tissue-Tolerated Temperature Range”
Carlos Morillo
February 1, 2022
Carlos Morillo
January 18, 2022
ABC-type triblock copolymers are a rising platform especially for oligonucleotide delivery as they offer an additional functionality besides the anyhow …
Continue reading “Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery”
Carlos Morillo
January 18, 2022
The vanillyl-alcohol oxidase (VAO) family is a rich source of biocatalysts for the oxidative bioconversion of phenolic compounds. Through genome …
Continue reading “Discovery, Biocatalytic Exploration and Structural Analysis of a 4-Ethylphenol Oxidase from Gulosibacter chungangensis”
Carlos Morillo
January 18, 2022
Treatment with rumen fluid improves methane production from non-degradable lignocellulosic biomass during subsequent methane fermentation; however, the kinetics of xylanases …
Continue reading “Shifts in xylanases and the microbial community associated with xylan biodegradation during treatment with rumen fluid”
Carlos Morillo
January 18, 2022
N-Linked glycosylation and O-linked N-acetylglucosamine (O-GlcNAc) are important protein post-translational modifications that are orchestrated by a diverse set of gene …
Continue reading “O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis”
Carlos Morillo
January 18, 2022
Although computational simulation-based natural product syntheses are in their initial stages of development, this concept can potentially become an indispensable …
Continue reading “Computation-guided asymmetric total syntheses of resveratrol dimers”
Carlos Morillo
February 24, 2022
Carlos Morillo
February 24, 2022
The co-catabolism of multiple host-derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, …
Continue reading “Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis”
Carlos Morillo
January 5, 2022