2021 / Scientific Report
Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function …
2021 / MDPI
In this work, the use of fluorescent molecular rotors such as 9-(2,2-dicyanovinyl)julolidine (DCVJ) and 2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl) phenyl)amino)phenyl)fumaronitrile (TPETPAFN) was proposed for …
2021 / Nature Communications, 12, Article number: 1530 (2021)
De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo …
Continue reading “Structural resolution of switchable states of a de novo peptide assembly”
2021 / Nature Communications
The design of efficient chiral catalysts is of crucial importance since it allows generating enantiomerically pure compounds. Tremendous efforts have …
2021 / Translational Psychiatry
d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which appear overactivated in AD, while d-aspartate is a modulatory molecule …
2021 / Bioscience, Biotechnology, and Biochemistry
Corydalis ambigua (Japanese name, Ezoengosaku) flowers bloom with blue to purplish petals in early spring in Hokkaido prefecture. In this …
2020 / Scientific Reports
Peptides provide a framework for generating functional biopolymers. In this study, the pH-dependent structural changes in the 21–29 fragment peptide …
Continue reading “pH-controlled stacking direction of the β-strands in peptide fibrils”
2020 / Nature Communications
A key feature that differentiates prokaryotic cells from eukaryotes is the absence of an intracellular membrane surrounding the chromosomal DNA. …
2020 / Nature Communications
Gramicidin A (1) is a peptide antibiotic that disrupts the transmembrane ion concentration gradient by forming an ion channel in …
2020 / Scientific Reports
The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase …
Continue reading “Multiple gene substitution by Target-AID base-editing technology in tomato”
2020 / Nature Communications volume 11, Article number: 4562 (2020)
Symmetry breaking and amplification processes have likely played a fundamental role in the development of homochirality on earth. Such processes …
2020 / Scientific Reports volume 10, Article number: 14657 (2020)
Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, …
2020 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume 241, 5 November 2020, 118645
Beer-Lambert-Bouguer law is for a limiting case and, therefore, it is not useful to describe the relationship between absorption signal …
2017 / Science Advances
Although previous studies have attempted to create “electronics-free” insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing …
2018 / Scientific Reports volume 8, Article number: 4433 (2018)
Over 12% of the world’s health resources are spent on treating diabetes, as high blood glucose is the third cause …
2020 / Nature Communications volume 11, Article number: 3944 (2020)
Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into organelles called lipid droplets (LDs). LDs are …
Continue reading “Triacylglycerols sequester monotopic membrane proteins to lipid droplets”
2020 / Scientific Reports volume 10, Article number: 11845 (2020)
Human milk oligosaccharides (HMOs) are a mixture of structurally diverse carbohydrates that contribute to shape a healthy gut microbiota composition. …
2020 / Communications Chemistry volume 3, Article number: 111 (2020)
Detection of nucleic acids is crucial to the study of their basic properties and consequently to applying this knowledge to …
Continue reading “Optical and theoretical study of strand recognition by nucleic acid probes”
2020 / Journal of Materials and Environmental Sciences, J. Mater. Environ. Sci., 2020, Volume 11, Issue 1, Page 79-84
The fruits of Pistacia lentiscus are a source of a fixed oil used in some forested areas for culinary purposes …
2014 / International Journal of Pharmacy and Pharmaceutical Sciences
Objective: The objective of the present work was to develop and validate a simple, fast, precise, selective and accurate RP-HPLC …
