The Coordination Abilities of New Cyclic Analogs of Somatostatin

By Aleksandra Marciniak, Marek Cebrat, Justyna Brasun

July 28, 2017

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Title

The Coordination Abilities of New Cyclic Analogs of Somatostatin

Author

Aleksandra Marciniak, Marek Cebrat, Justyna Brasun

Year

2016

Journal

International Journal of Peptide Research and Therapeutics

Abstract

Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with NIm; 3N amide binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed. K

Full Article

http://link.springer.com/article/10.1007/s10989-016-9546-4

Instrument

J-1500

Keywords

Magnetic circular dichroism, Ligand binding, Coordination chemistry, Biochemistry