The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding

By Aleksandra Kotynia, Edward Krzyżak, Elżbieta Kamysz, Małgorzata Sobocińska, Justyna Brasuń

July 28, 2017

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Title

The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding

Author

Aleksandra Kotynia, Edward Krzyżak, Elżbieta Kamysz, Małgorzata Sobocińska, Justyna Brasuń

Year

2017

Journal

International Journal of Peptide Research and Therapeutics

Abstract

Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.

Full Article

http://link.springer.com/article/10.1007/s10989-016-9569-x

Instrument

J-1500

Keywords

Circular dichroism, Magnetic circular dichroism, Coordination chemistry, Biochemistry