Title
Three new lignanosides from the aerial parts of Lespedeza cuneata
Author
Chuang-Feng Zhang, Jian Zhou, Jing-Zhi Yang, Chuang-Jun Li, Jie Ma, Dan Zhang, Li Li, Dong-Ming Zhang
Year
2016
Journal
Journal of Asian Natural Products Research
Abstract
Three new lignanosides (+)-(8S,7′S,8′S)-burselignan-9′-O-β-d-glucopyrano side (1), (+)-(8R,7′S,8′R)-isolariciresinol-9′-O-β-d-fucopyranoside (2), (-)-(8S, 7′R,8′R)-methoxyisoariciresinol-9′-O-α-l-rhamnoside (3), along with four known compounds, were isolated from the aerial parts of Lespedeza cuneata (Dum.Cours.) G.Don. The fucopyranoside has not been reported in this genus previously. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature. Compounds 2 and 6 showed moderate hepatoprotective activities.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Medicinal