Title
Three novel indole alkaloids from Kopsia officinalis
Author
Zhi-Wei Wang, Xiao-Jian Shi, Yan Mu, Lei Fang, Yue Chen, Yun-Liang Lin
Year
2017
Journal
Fitoterapia
Abstract
Three new indole alkaloids, named kopsioffines A–C (1–3), possessing relatively novel ten-membered lactam ring, and one known compound (11,12-demethoxy-16-deoxypauciflorine, 4) were isolated from the leaves and stems of Kopsia officinalis. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of 1 was determined by calculated electronic circular dichroism data. The hypothetical biosynthetic pathway of 1 was postulated. All these isolates were evaluated for their inhibitory effects on α-glucosidase. None of them showed activity with IC50 far beyond 50 μM.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal