Title
Two new bisabolane-type sesquiterpenoids from the cooking liquid of Curcuma longa rhizomes
Author
Xiaoli Cheng, Hanxiang Li, Ping Wu, Liangxiong Xu, Jinghua Xue, Xiaoyi Wei
Year
2019
Journal
Phytochemistry Letters
Abstract
Two new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid of Curcuma longa rhizomes. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configurations of compounds 1 and 2 were assigned by electronic circular dichroism (ECD) calculations. Compound 2 exhibited in vitro anti-inflammatory activity with an IC50value of 25.5 ± 3.1 μM comparable to that of the positive control.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Agriculture and environmental