Two new diterpenoids from the endophytic fungus Trichodermasp. Xy24 isolated from mangrove plant Xylocarpus granatum
Min Zhang, Ji-Mei Liu, Jin-Lian Zhao, Ning Li, Ri-Dao Chen, Ke-Bo Xie, Wen-Jing Zhang, Ke-Ping Feng, Zheng Yan, Nan Wang, Jun-Gui Dai
Chinese Chemical Letters
Two new harziane diterpenoids, named (9R,10R)-dihydro-harzianone (1) and harzianelactone (2), were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic (HR-ESI-MS, 1D NMR, 2D NMR and CD) analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer–Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against HeLa and MCF-7 cell lines with IC50 values of 30.1 μmol/L and 30.7 μmol/L, respectively.
Circular dichroism, Stereochemistry, Medicinal