Title
Two New Pyrrolidine Alkaloids, Radicamines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR
Author
Makio Shibano, Daisuke Tsukamoto, Atsuko Masuda, Yasuko Tanaka, Genjiro Kusano
Year
2001
Journal
Chemical and Pharmaceutical Bulletin
Abstract
Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of α-glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.
Instrument
J-820
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical