Title
Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex
Author
Ondrej Hrabina, Jana Kasparkova, Teresa Suchankova, Vojtech Novohradsky, Zijian Guo, Viktor Brabec
Year
2017
Journal
Metallomics
Abstract
The DNA interstrand cross-links of the antitumor drug ({[cis-Pt(NH3)2Cl]2(4,4´-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms in DNA long-range interstrand cross-links uniquely in the 3'-3' direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.
Instrument
J-720
Keywords
Circular dichroism, DNA structure, Biochemistry