Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of “fu zi”: Neoline 14-O-l-arabinosides with four isomeric l-anabinosyls

By Xian-Hua Meng, Qing-Lan Guo, Cheng-Gen Zhu, Jian-Gong Shi

July 28, 2017

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Title

Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of “fu zi”: Neoline 14-O-l-arabinosides with four isomeric l-anabinosyls

Author

Xian-Hua Meng, Qing-Lan Guo, Cheng-Gen Zhu, Jian-Gong Shi

Year

2017

Journal

Chinese Chemical Letters

Abstract

Four structurally unprecedented aconitane-type C19-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D (1–4), were isolated from an aqueous extract of “fu zi”, the lateral roots of Aconitum carmichaelii. Their structures were elucidated by spectroscopic and chemical methods, including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic aconitane diterpenoid alkaloids.

Full Article

http://www.sciencedirect.com/science/article/pii/S1001841717301638

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal