Title
Volumetric additive manufacturing of pristine silk-based (bio)inks
Author
Maobin Xie, Liming Lian, Xuan Mu, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Zhenrui Zhang, Arturo López, Jennifer Manríquez, Xiao Kuang, Junqi Wu, Jugal Kishore Sahoo, Federico Zertuche González, Gang Li, Guosheng Tang, Sushila Maharjan, Jie Guo, David L. Kaplan & Yu Shrike Zhang
Year
2023
Journal
Nature Communications
Abstract
Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, the lack of bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Of interest, combined with post-fabrication processing, the (bio)printed SS constructs reveal properties including reversible as well as repeated shrinkage and expansion, or shape-memory; whereas the (bio)printed SF constructs exhibit tunable mechanical performances ranging from a few hundred Pa to hundreds of MPa. Both types of silk-based (bio)inks are cytocompatible. This work supplies expanded bioink libraries for VAM and provides a path forward for rapid volumetric manufacturing of silk constructs, towards broadened biomedical applications.
Full Article
Instrument
FT/IR-6200
Keywords
VAM, biomedical, bioinks,