Analysis of Crystal Polymorphism by Raman Spectroscopy for Medicine Development

May 4, 2017

Introduction

Crystal polymorphism is a phenomenon where compounds with the same chemical formula can be crystallized into different crystal structures. The crystal structure depends on the conditions (such as temperature and pressure) used in the crystal formation process. The resulting crystal structures are conveniently classified as Form I, II, III or Ta and Tb.

In medicine, the solubility, stability and bio-availability will depend on the crystal polymorphism; compounds with different crystal structures may be recognized as different compounds. Therefore, research into crystal polymorphism is widely used in areas such as:- basic study, structure/function correlation of compounds and industrial applications such as patent application.

Therefore, in the pharmaceutical industry, the study of crystal formation techniques is very important for the control of crystal structure and the manufacture of high quality medicines.

Micro-Raman Spectrometer (NRS-5000)
  • Impurity Analysis (Identification of micro impurity with sizes less than 1 um)
  • Evaluation of Synthetic (Structural analysis in combination with IR)
  • Mapping (Evaluation of tablet for DDS research)
  • PAT (Real-time control in medicine production process)

Evaluation of Crystal Polymorphism (Evaluation method instead of XRD and DSC)

About the Author

Leah Pandiscia received her PhD from Drexel University where she studied Biophysical Chemistry. She is a Spectroscopy Applications Scientist at JASCO.