Home / Applications / Chiral Analysis of Flurbiprofen using a Circular Dichroism Detector

Chiral Analysis of Flurbiprofen using a Circular Dichroism Detector

By Miyuki Kanno

Introduction

Flurbiprofen is a non-steroidal anti-inflammatory drug and used as a topical medical patch or an internal medicine. The S enantiomer of flurbiprofen, accounts for the majority of the pharmacological activity.

The Circular Dichroism detector is well known for its high accuracy and selectivity for chiral analysis of compounds that have chromophores close to the chiral center. Both CD and UV signal are measured simultaneously and spectral scanning can be used to optimize the wavelength of interest, which is important in the measurement of chiral compounds. Not only can the CD detector help differentiate between two enantiomers, but it can also distinguish between achiral impurities and enantiomers of interest.

Keywords

101017H

Results

Fig. 1 shows the chromatograms of the racemic flurbiprofen standard. Fig. 2 CD and UV spectra (measured using stopped-flow).

Chromatogram of Flurbiprofen standard, spectral measurement

This document has been prepared based on information available at the time of publication and is subject to revision without notice. Although the contents are checked with the utmost care, we do not guarantee their accuracy or completeness. JASCO Corporation assumes no responsibility or liability for any loss or damage incurred as a result of the use of any information contained in this document. Copyright and other intellectual property rights in this document remain the property of JASCO Corporation. Please do not attempt to copy, modify, redistribute, or sell etc. in whole or in part without prior written permission.