Leah Pandiscia, PhD
March 24, 2020
Polymorphism in the alcohol dehydrogenase (ADH) protein of Drosophila melanogaster, like genetic variation in many other enzymes, has long been hypothesized… Continue reading Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster
Leah Pandiscia, PhD
March 24, 2020
While biologic drugs such as proteins, peptides, or nucleic acids have shown promise in the treatment of neurodegenerative diseases, the… Continue reading Targeting Ligands Deliver Model Drug Cargo into the Central Nervous System along Autonomic Neurons
Leah Pandiscia, PhD
March 24, 2020
Ligand-switch reactions at the heme iron are common in biological systems, but their mechanisms and the features of the polypeptide… Continue reading A Heme Propionate Staples the Structure of Cytochrome c for Methionine Ligation to the Heme Iron
Leah Pandiscia, PhD
March 24, 2020
An aptamer-amphiphile was designed that binds to β-lactoglobulin (β-LG), a major allergen from cow’s milk. For this work, a 23-nucleotide… Continue reading Design of an Aptamer-Amphiphile for the Detection of β-Lactoglobulin on a Liquid Crystal Interface
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Peptide amphiphile micelles (PAMs) are a powerful platform technology for improving the delivery of therapeutic and prophylactic peptides. While previous… Continue reading Therapeutic peptide delivery via aptamer-displaying, disulfide-linked peptide amphiphile micelles
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Metal dyshomeostasis is central to a number of disorders that result from, inter alia, oxidative stress, protein misfolding, and cholesterol… Continue reading Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
June 29, 2020
Phosphorylation is one of the main regulators of cellular signaling typically occurring in flexible parts of folded proteins and in… Continue reading Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range
Leah Pandiscia, PhD
March 24, 2020
We have systematically prepared three kinds of photosensitizing (PS) double layers on the surface of Pt-cocatalyst-loaded TiO2 (Pt-TiO2) nanoparticles by using… Continue reading A Systematic Study on the Double-Layered Photosensitizing Dye Structure on the Surface of Pt-Cocatalyst-Loaded TiO2 Nanoparticles
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The current study investigated the binding of BSA and piperacillin at multifarious concentrations (1–128 μM) along with four different temperatures. To… Continue reading Kinetic and thermodynamic insights into interaction of albumin with piperacillin: Spectroscopic and molecular modeling approaches
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The sorption of uranium and thorium from their aqueous solutions by using 8-hydroxyquinoline modified Na-bentonite (HQ-bentonite) was investigated by the… Continue reading The Removal of Uranium and Thorium from Their Aqueous Solutions by 8-Hydroxyquinoline Immobilized Bentonite
Leah Pandiscia, PhD
March 24, 2020
Three binuclear Schiff base copper(II) complexes: [Cu2(HL1)2(CH3OH)(NO3)]·NO3 (1), [Cu2(HL2)2(CH3OH)2]·2NO3 (2), and [Cu2(HL3)2(C2H5OH)2]·2NO3 (3) [HL1 = (E)-N′-(5-fluoro-2-hydroxybenzylidene)benzohydrazide, HL2 = (E)-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide, and HL3 = (E)-N′-(5-bromo-2-hydroxybenzylidene)benzohydrazide], were synthesized and characterized employing various… Continue reading Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties
Leah Pandiscia, PhD
March 24, 2020
A new tri-imidazolium salt, tris(4-(3-(2-((8-hydroxy-9,10-dioxo-9′,10′-dihydroanthracen-1-yl)oxy)ethyl)-1H-imidazole-3′-ium-1′-yl)phenyl)amine hexafluorophosphate was prepared and characterized. Particularly, the recognition performance of the tri-imidazolium salt for cations… Continue reading A new tridentate fluorescent-colorimetric chemosensor for copper(II) ion
Leah Pandiscia, PhD
March 24, 2020