Nanoparticle mediated extracellular matrix may offer new and improved biomaterial to wound healing and tissue engineering applications. However, influence of… Continue reading Role of nanoparticle size in self-assemble processes of collagen for tissue engineering application
Leah Pandiscia, PhD
July 28, 2017
Eight new γ-lactam alkaloids, hemerominors A-H (1–8), including two pair of epimers (1–4), together with six known compounds (9–14) were… Continue reading Eight new γ-lactam alkaloids from the roots of the Hemerocallis minor Mill
Leah Pandiscia, PhD
July 28, 2017
Peptide-coated nanoparticles are valuable tools for diverse biological applications, such as drug delivery, molecular recognition, and antimicrobial action. The functionalization… Continue reading Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility
Leah Pandiscia, PhD
July 28, 2017
This work presents an amplified colorimetric biosensor for circulating tumor DNA (ctDNA), which associates the hybridization chain reaction (HCR) amplification… Continue reading Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA
Leah Pandiscia, PhD
July 28, 2017
Surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization has been utilized to fabricate high-capacity strong anion-exchange (AEX) membrane for the separation… Continue reading Fabrication of high-capacity polyelectrolyte brush-grafted porous AAO-silica composite membrane via RAFT polymerization
Leah Pandiscia, PhD
July 28, 2017
Circularly polarized luminescent (CPL) materials are currently attracting great interest. While a chiral building is usually necessary in order to… Continue reading Full-Color Tunable Circularly Polarized Luminescent Nanoassemblies of Achiral AIEgens in Confined Chiral Nanotubes
Leah Pandiscia, PhD
May 24, 2018
The traditional surfactant sodium dodecyl sulfate (SDS) and ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim][BF4]) have been combined to create a novel… Continue reading A novel efficient medium for chromogenic catalysis of tetramethylbenzidine with horseradish peroxidase
Leah Pandiscia, PhD
July 28, 2017
Tuberculosis, a contagious disease of infectious origin is currently a major cause of deaths worldwide. Mycobacterium indicus pranii (MIP), a saprophytic non-pathogen… Continue reading Immunodominant protein MIP_05962 from Mycobacterium indicus pranii displays chaperone activity
Leah Pandiscia, PhD
July 28, 2017
The central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity.… Continue reading Auto-phosphorylation Represses Protein Kinase R Activity
Leah Pandiscia, PhD
July 28, 2017
A facile approach was developed to immobilize gold nanoparticles (AuNPs) onto peptide nanofibers for catalytic applications. In this study, fluorenylmethoxycarbonyl… Continue reading Co-assembly of Fmoc-tripeptide and gold nanoparticles as a facile approach to immobilize nanocatalysts
Leah Pandiscia, PhD
July 28, 2017
Two chiral binaphthyl-based enantiomers, (R/S)-7, were designed and synthesized by Sonogashira cross-coupling reaction of AIE-active TPE and O-BOPHY. Interestingly, the resulting… Continue reading Reversal aggregation-induced circular dichroism from axial chirality transfervia self-assembled helical nanowires
Leah Pandiscia, PhD
July 28, 2017
Complexes of Eu(III)(hfa)3 with a C2-symmetric planar P(III) ligand exhibited intense circularly polarised luminescence (CPL) due to 5D0→7F1 and 5D0→7F2 transitions, with the signs and shapes… Continue reading Complexes of Eu(III)(hfa)3 with a planar chiral P(III) ligand (Phanephos): solvent-sensitive sign inversion of circularly polarised luminescence
Leah Pandiscia, PhD
May 24, 2018
Deep eutectic solvents (DES) have recently been postulated as possible environments where protein structure may be preserved in the absence… Continue reading Protein conformation in pure and hydrated deep eutectic solvents
Leah Pandiscia, PhD
July 28, 2017
Employing induced asymmetric synthesis, new decasubstituted pillar[5]arenes containing (R)-(+)- or (S)-(−)-1-phenylethane-1-acetamide fragments have been obtained and characterized. Using NTA and… Continue reading Synthesis and properties of chiral nanoparticles based on (pS)- and (pR)-decasubstituted pillar[5]arenes containing secondary amide fragments
Leah Pandiscia, PhD
July 28, 2017
We describe the synthesis and pairing properties of the novel DNA analogue 7′,5′-bicyclo(bc)-DNA. In this analogue, the point of attachment… Continue reading Probing the backbone topology of DNA: synthesis and properties of 7′,5′-bicyclo-DNA
Leah Pandiscia, PhD
July 28, 2017
G-rich DNA oligonucleotides derived from the promoter region of the HIV-1 Long Terminal Repeat (LTR) were assembled onto an addressable… Continue reading Template mediated stabilization of a DNA G-quadruplex formed in the HIV-1 promoter and comparative binding studies
Leah Pandiscia, PhD
July 28, 2017
Viral infection induces translocation of the nucleolar protein GLTSCR2 from the nucleus to the cytoplasm, resulting in attenuation of the… Continue reading Cellular protein GLTSCR2: A valuable target for the development of broad-spectrum antivirals
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In spite of the fact that amyloid related neurodegenerative illnesses and non-neuropathic systemic amyloidosis have allured the research endeavors, as… Continue reading Anti-Parkinsonian L-Dopa can also act as anti-systemic amyloidosis—A mechanistic exploration
Leah Pandiscia, PhD
July 28, 2017
Having a high folding efficiency and a low tendency to aggregate, the superfolder GFP (sfGFP) offers a unique opportunity to… Continue reading Distinct Effects of Guanidine Thiocyanate on the Structure of Superfolder GFP
Leah Pandiscia, PhD
July 28, 2017