Leah Pandiscia, PhD
July 28, 2017
This article is related to http://dx.doi.org/10.1016/j.bbamem.2017.01.005 (Ø. Strømland, Ø.S. Handegård, M.L. Govasli, H. Wen, Ø. Halskau, 2017) [1]. In protein and polypeptide-membrane interaction… Continue reading Spectroscopic and AFM characterization of polypeptide-surface interactions: Controls and lipid quantitative analyses
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Protein oxidation can influence the quality of food during processing and storage. In the present study, the sensitivity of ovalbumin… Continue reading Effects of Lipid Peroxide on the Structure and Gel Properties of Ovalbumin
Leah Pandiscia, PhD
July 28, 2017
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress granules. In vitro, stress-granule-associated proteins can demix to form liquids,… Continue reading Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
Leah Pandiscia, PhD
July 28, 2017
Rapid methods for the detection and clinical treatment of human norovirus (HuNoV) are needed to control foodborne disease outbreaks, but… Continue reading Exploration of the metal coordination region of concanavalin A for its interaction with human norovirus
Leah Pandiscia, PhD
July 28, 2017
Collagen fibrils accumulate in excessive amounts and impair the normal functioning of the organ; therefore it stimulates the interest for… Continue reading Exploiting oleuropein for inhibiting collagen fibril formation
Leah Pandiscia, PhD
July 28, 2017
Some modified glucagon-like-peptide-1 (GLP-1) analogs are highly important for treating type 2 diabetes. Here we investigated whether GLP-1 analogs expressed… Continue reading Semi-microbiological synthesis of an active lysinoalanine-bridged analog of glucagon-like-peptide-1
Leah Pandiscia, PhD
July 28, 2017
Five new koumine-type alkaloids (1–5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with… Continue reading Five new koumine-type alkaloids from the roots of Gelsemium elegans
Leah Pandiscia, PhD
July 28, 2017
Age related cataract is a major cause of visual loss worldwide that is a result of opacification of the eye… Continue reading Green tea flavanols protect human γB-crystallin from oxidative photodamage
Leah Pandiscia, PhD
July 28, 2017
This paper describes the synthesis of a novel series of acridine thiosemicarbazones through a two-step reaction between various isothiocyanates and… Continue reading 3-[(E)-(acridin-9′-ylmethylidene)amino]-1-substituted thioureas and their biological activity
Leah Pandiscia, PhD
July 28, 2017
As a continuation of our efforts directed to the structure-activity relationship studies of vitamin D compounds, we present in this… Continue reading Design, Synthesis and Biological Properties of Seco-D-Ring Modified 1α,25-Dihydroxyvitamin D3 Analogues
Leah Pandiscia, PhD
July 28, 2017
Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein… Continue reading Minimized natural versions of fungal ribotoxins show improved active site plasticity
Leah Pandiscia, PhD
July 28, 2017
One new indoloditerpene, 6,7-dehydropaxilline (1), one new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3), as well… Continue reading Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities
Leah Pandiscia, PhD
July 28, 2017
Supramolecular bioarchitectures formed by assembly of achiral or chiral building blocks play important roles in various biochemical processes. Stereochemistry of… Continue reading Controlled enzymatic stability and release characteristics of supramolecular chiral peptide amphiphile nanofiber gels
Leah Pandiscia, PhD
July 28, 2017
Several unconventional myosins contain a highly charged single α helix (SAH) immediately following the calmodulin (CaM) binding IQ motifs, functioning… Continue reading Ca2+-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single α Helix Lever Arm Extension
Leah Pandiscia, PhD
July 28, 2017
Glutathione S-transferase A3-3 is the most catalytically efficient steroid isomerase enzyme known in humans, transforming Δ5-androstene-3-17-dione into Δ4-androstene-3-17-dione. GSTA3-3 catalyzes this… Continue reading The effects of mutating Tyr9 and Arg15 on the structure, stability, conformational dynamics and mechanism of GSTA3-3
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The binding of irinotecan, a potent anti cancer drug, to bovine beta-lactoglobulin (β-LG) was investigated by various spectroscopic techniques including… Continue reading Irinotecan binds to the internal cavity of beta-lactoglobulin: A multi-spectroscopic and computational investigation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017