The metastasis suppressor KISS1 is reported to be involved in the progression of several solid neoplasias, making it a promising… Continue reading The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Albendazole (ABZ) is a sulfanyl-benzimidazole anthelmintic drug used worldwide in the treatment and prevention of parasitic diseases in animals and… Continue reading The sodium salt of the enantiomers of ricobendazole: Preparation, solubility and chiroptical properties
Leah Pandiscia, PhD
July 28, 2017
Hydrogel as a carrier for drug delivery system has been developed, but it is hard to change the load and… Continue reading Coassembly Modulated pH-Responsive Hydrogel for Dye Absorption and Release
Leah Pandiscia, PhD
July 28, 2017
Novel chiral pyrene-binaphthalene compounds, (R)-/(S)-(13Z,21bZ)-dinaphtho[2,1-e:1′,2′-g]pyreno[4,5-b][1,4]diazocine (1) and (R)-/(S)-(3bZ,5Z,7Z,9Z,12bZ,14Z,16Z,18Z)-bis(dinaphtho[2,1-e:1′,2′-g])pyreno[4,5-b:9,10-b′]bis([1,4]diazocine) (2), were synthesized and characterized by a series of spectroscopic methods including… Continue reading Novel chiral binaphthalene-linked pyrenes. Synthesis, structure, and spectroscopy
Leah Pandiscia, PhD
July 28, 2017
Extraction and separation of proteins is important for their interesting applications as continuous enzymatic reaction and/or product separation systems. In… Continue reading Homogeneous capture and heterogeneous separation of proteins by PEG-functionalized ionic liquid–water systems
Leah Pandiscia, PhD
July 28, 2017
Protein-drug interaction offer information of the structural features that determine the therapeutic effectiveness of drug and have become an attractive… Continue reading Thermodynamics and binding mechanism of polyphenon-60 with human lysozyme elucidated by calorimetric and spectroscopic techniques
Leah Pandiscia, PhD
July 28, 2017
Deposition of amyloid- plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein… Continue reading HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity
Leah Pandiscia, PhD
July 28, 2017
Hydroxypropyl methylcellulose (HPMC) and xyloglucan (XG) crosslinked with citric acid over a range of HPMC/XG weight ratios formed sustainable blend… Continue reading Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
G-quadruplexes (G4s) are high-order secondary structures that modulate several key cell processes such as telomere function, gene expression and DNA… Continue reading Study of the interaction between indole-based compounds and biologically relevant G-quadruplexes
Leah Pandiscia, PhD
July 28, 2017
ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here we show that the α-helical,… Continue reading BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy
Leah Pandiscia, PhD
July 28, 2017
Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon… Continue reading Peptide oligomers from ultra-short peptides using sortase
Leah Pandiscia, PhD
July 28, 2017
Protein function originates from a cooperation of structural rigidity, dynamics at different timescales, and allostery. However, how these three pillars… Continue reading Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery
Leah Pandiscia, PhD
July 28, 2017
Nanoparticles (NPs) can have profound effects on cell biology. However, the potential adverse effects of gold nanoparticles (AuNPs) with different… Continue reading Cytotoxicity of gold nanoparticles with different structures and surface-anchored chiral polymers
Leah Pandiscia, PhD
July 28, 2017
Coiled coils, consisting of at least two α-helices, have important roles in the regulation of transcription, cell differentiation, and cell… Continue reading Heterochiral Jun and Fos bZIP peptides form a coiled-coil heterodimer that is competent for DNA binding
Leah Pandiscia, PhD
July 28, 2017
Seven anthraquinones were isolated from aerial parts of Heterophyllaea lycioides (Rusby) Sandwith (Rubiaceae), including three derivatives that have not been described before:… Continue reading Photosensitizing anthraquinones from Heterophyllaea lycioides (Rubiaceae)
Leah Pandiscia, PhD
July 28, 2017
Diaminopimelate epimerase (DapF) is one of the crucial enzymes involved in L-lysine biosynthesis, where it converts L,L-diaminopimelate (L,L-DAP) into D,L-DAP. DapF is also… Continue reading Structural basis for redox sensitivity in Corynebacterium glutamicumdiaminopimelate epimerase: an enzyme involved in L-lysine biosynthesis
Leah Pandiscia, PhD
July 28, 2017
Achiral stilbene polycatenars forming smectic, columnar or cubic phase depending on the terminal chains length, were studied. The cubic Im3m… Continue reading Optically active cubic liquid crystalline phase made of achiral polycatenar stilbene derivatives
Leah Pandiscia, PhD
July 28, 2017
We are currently investigating self-assembled nanostructures from short oligomers of β-amino acids and their subsequent use as drug delivery systems.… Continue reading Self-assembled amphiphilic mixed α/β-tetrapeptoid nanostructures as promising drug delivery vehicles
Leah Pandiscia, PhD
July 28, 2017