Secondary structures in 5′ UTR of mRNAs play a critical role in regulating protein synthesis. Though studies have indicated the… Continue reading Role of G-quadruplex located at 5ʹ end of mRNAs
Leah Pandiscia, PhD
July 28, 2017
Perfluorinated compounds (PFCs) have been shown to disrupt lipid metabolism and even induce cancer in rodents through activation of peroxisome… Continue reading Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
One way to gain information about the fusogenic potential of virus-derived synthetic peptides is to examine their interfacial properties and… Continue reading Effect of E1(64–81) hepatitis G peptide on the in vitrointeraction of HIV-1 fusion peptide with membrane models
Leah Pandiscia, PhD
July 28, 2017
A new generation multi-component vaccine, principally directed against serogroup B Neisseria meningitidis (4CMenB), has recently been developed. One of its components, identified… Continue reading Structural characterisation, stability and antibody recognition of chimeric NHBA-GNA1030: An investigational vaccine component against Neisseria meningitidis
Leah Pandiscia, PhD
July 28, 2017
Quaking (QkI) is a prototypical member of the STAR (signal transducer and activator of RNA) protein family, which plays key roles in posttranscriptional… Continue reading Structural Analysis of the Quaking Homodimerization Interface
Leah Pandiscia, PhD
July 28, 2017
MCPH1 is especially important for linking chromatin remodeling to DNA damage response. It contains three BRCT (BRCA1-carboxyl terminal) domains. The… Continue reading Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
In this work, we developed a sensitive and selective sensor technique for total mercury (Hg) detection in canned fish samples… Continue reading A reusable and sensitive biosensor for total mercury in canned fish based on fluorescence polarization
Leah Pandiscia, PhD
July 28, 2017
2-Hydroxybutyl-β-cyclodextrins (HB-β-CyDs) with different degrees of substitution (D.S.) were prepared and their physicochemical and biological properties and solubilizing abilities were… Continue reading Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Detection of reactive oxygen species (ROS) is important in varied biological processes, disease diagnostics, and chemotherapeutic drug screening. We constructed… Continue reading Detection of Reactive Oxygen Species (ROS) by a Carbon-Dot-Ascorbic Acid Hydrogel
Leah Pandiscia, PhD
July 28, 2017
Three copper(II) complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)pheamine, Cu(Sal-Gly)phepoxy were synthesized and characterized for their anticancer properties and mechanism of action (Acilan et… Continue reading Validation data supporting the characterization of novel copper complexes as anticancer agents
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Silver nanoparticles (AgNPs) with an average particle size of 20 nm were synthesized by using aromatic amino acid fluorescence active, tryptophan… Continue reading Protein interactions with silver nanoparticles: Green synthesis, and biophysical approach
Leah Pandiscia, PhD
July 28, 2017
Because of the toxicity of hydrogen sulfide and its important role in various physiological processes, the development of a selective… Continue reading A colorimetric sensor for hydrogen sulfide detection using direct inhibition of active site in G-quadruplex DNAzyme
Leah Pandiscia, PhD
July 28, 2017
Fluorescent sensing of G-quadruplex nucleic acids (G4s) is an effective strategy to elucidate their role in vitro and in vivo.… Continue reading G-quadruplex fluorescence sensing by core-extended naphthalene diimides
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Chiral D- and L-N-acryloyl aspartic acid (NAsp) polyelectrolyte (PE) surfaces with similar chemical compositions and physical properties but opposite chirality… Continue reading Immobilization of Enzyme on Chiral Polyelectrolyte Surface
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017