Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) are promising candidates for new antibiotic classes but often display an unacceptably high toxicity towards human cells.… Continue reading PGLa-H tandem-repeat peptides active against multidrug resistant clinical bacterial isolates
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two novel imidazopyridinium cations formed by a hexacyclic azonia aromatic system have been synthesized. Spectrofluorimetric titrations, circular dichroism measurements, theoretical… Continue reading Imidazopyridinium cations: A new family of azonia aromatic heterocycles with applications as DNA intercalators
Leah Pandiscia, PhD
July 28, 2017
A new chiral tetraphenylethene derivative with two l-leucine-containing attachments, TPE-DLEU, has been designed and synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition “click” reaction.… Continue reading Circularly polarized luminescence and controllable helical self-assembly of an aggregation-induced emission luminogen
Leah Pandiscia, PhD
May 24, 2018
Antimicrobial peptides are biologically active molecules produced by a wide range of organisms as an essential component of the innate… Continue reading Novel designed VmCT1 analogs with increased antimicrobial activity
Leah Pandiscia, PhD
July 28, 2017
Currently prostate specific antigen (PSA) serum concentration is the most used prostate cancer marker, but it only shows limited specificity.… Continue reading Sample preparation of serum to allow capillary electrophoresis analysis of prostate specific antigen isoforms
Leah Pandiscia, PhD
July 28, 2017
The healing of chronic wounds remains a key challenge in regenerative medicine. To promote wound healing, a bioactive wound dressing… Continue reading Functionalized silk fibroin dressing with topical bioactive insulin release for accelerated chronic wound healing
Leah Pandiscia, PhD
July 28, 2017
It was recently reported that dropping induces protein aggregation due to the occurrence of cavitation. Agitation also causes protein aggregation.… Continue reading Synergistic Effect of Cavitation and Agitation on Protein Aggregation
Leah Pandiscia, PhD
July 28, 2017
The partitioned n-hexane, CHCl3, and EtOAc extracts from the crude MeOH extract of Phaius mishmensisshowed considerable cytotoxicities against the human breast carcinoma… Continue reading Chemical Constituents of Phaius mishmensis
Leah Pandiscia, PhD
July 28, 2017
Elucidating molecular mechanisms of host-parasite interaction during red cell invasion by Plasmodium is important to develop newer antimalarial therapeutics. Recently,… Continue reading Basigin interacts with Plasmodium vivax tryptophan-rich antigen PvTRAg38 as a second erythrocyte receptor to promote parasite growth
Leah Pandiscia, PhD
July 28, 2017
Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example… Continue reading Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Five rare dichloro aromatic polyketides (1–5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6–10). Their structures… Continue reading Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.
Leah Pandiscia, PhD
July 28, 2017
WhmD is considered to have a role in the septation and division Mycobacterium smegmatis cells. Since FtsZ is the central protein of… Continue reading WhmD promotes the assembly of Mycobacterium smegmatisFtsZ: A possible role of WhmD in bacterial cell division
Leah Pandiscia, PhD
July 28, 2017
G-quadruplex (G4) are found at important genome regions such as telomere ends and oncogene promoters. One prominent strategy to explore… Continue reading Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes
Leah Pandiscia, PhD
July 28, 2017
The Oct4 gene codes for a transcription factor that plays a critical role in the maintenance of pluripotency in embryonic… Continue reading G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The Hsp100 chaperones ClpB and Hsp104 utilize the energy from ATP hydrolysis to reactivate aggregated proteins in concert with the… Continue reading The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride
Leah Pandiscia, PhD
July 28, 2017