Title
Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.
Author
Ming-Hua Yang, Tian-Xiao Li, Ying Wang, Rui-Huan Liu, Jun Luo, Ling-Yi Kong
Year
2016
Journal
Fitoterapia
Abstract
Five rare dichloro aromatic polyketides (1–5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6–10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compounds 2–4 and 6 structurally involved acyclic 1.3-diols, the uneasy configuration determinations of which were well carried out by double-derivation NMR methods. Compounds 1–10were evaluated for their antibacterial and antifungal activities against five strains of human pathogenic microorganisms. Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6 μg/mL, respectively.
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Natural products, Medicinal