In this work, binding of garlic component-Diallysulfide (DAS) with major human blood transport protein, Human Serum Albumin (HSA) and its… Continue reading Anti-amyloidogenic behavior and interaction of Diallylsulfide with Human Serum Albumin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The chaperone-like activity of αA-crystallin has an important role in maintaining lens transparency. Previously we identified residues 70–88 as a… Continue reading Structural and Functional Consequences of Chaperone Site Deletion in αA-Crystallin
Leah Pandiscia, PhD
July 28, 2017
Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators… Continue reading The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Human Cellular Retinol Binding Protein II (hCRBPII), a member of the intracellular lipid-binding protein family, is a monomeric protein responsible… Continue reading Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates
Leah Pandiscia, PhD
July 28, 2017
Four interesting sequoiatones stereoisomers (1–4) were isolated from a wetland soil-derived fungus Talaromyces flavus by chiral HPLC. On the basis of comprehensive… Continue reading A set of interesting sequoiatones stereoisomers from a wetland soil-derived fungus Talaromyces flavus
Leah Pandiscia, PhD
July 28, 2017
Ochratoxin A (OTA), a toxin produced by Aspergillus ochraceus and Penicillium verrucosum, is one of the most abundant food-contaminating mycotoxins worldwide. OTA mainly exerts… Continue reading Nuclease-aided target recycling signal amplification strategy for ochratoxin A monitoring
Leah Pandiscia, PhD
July 28, 2017
The nucleocapsidic protein (NC) of orthoretroviruses has been considered as a promising target for antiretroviral drugs. Compounds, including zinc ejectors… Continue reading Spectroscopic Investigation of Auranofin Binding to Zinc Finger HIV-2 Nucleocapsid Peptides
Leah Pandiscia, PhD
July 28, 2017
Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs… Continue reading Polyphenolic glycosides isolated from Pogostemon cablin(Blanco) Benth. as novel influenza neuraminidase inhibitors
Leah Pandiscia, PhD
July 28, 2017
X-ray diffractometry dominates protein studies, as it can provide 3D structures of these diverse macromolecules or their molecular complexes with… Continue reading Intrinsic protein disorder could be overlooked in cocrystallization conditions – An SRCD case study
Leah Pandiscia, PhD
July 28, 2017
Obtaining sufficient quantities of recombinant M.tb proteins using traditional approaches is often unsuccessful. Several enzymes of the glycolytic cycle are… Continue reading Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv
Leah Pandiscia, PhD
July 28, 2017
Three new sesquiterpenoids (1–3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The… Continue reading Three new sesquiterpenoids from agarwood of Aquilaria crassna
Leah Pandiscia, PhD
July 28, 2017
Pseudomonas aeruginosa acquires extracellular heme via the Phu (Pseudomonas heme uptake) and Has (heme assimilation system) systems. We have previously… Continue reading Metabolite Driven Regulation of Heme Uptake by the Biliverdin IXβ/δ Selective HemO of Pseudomonas aeruginosa.
Leah Pandiscia, PhD
July 28, 2017
Pif is a crucial protein for the formation of the nacreous layer in Pinctada fucata. Three non-acidic peptide fragments of… Continue reading Study of Binding Interaction between Pif80 Protein Fragment and Aragonite
Leah Pandiscia, PhD
July 28, 2017
A series of di-, tri- and tetra-peptides were synthesised using L- and D-glutamic acid in order to determine the effects of peptide… Continue reading The impact of structural variation in simple lanthanide binding peptides
Leah Pandiscia, PhD
July 28, 2017
Over the past few years, chiral supramolecular assemblies have been successfully used for recognition, sensing and enantioselective transformations. Several approaches… Continue reading Generation of a Chiral Giant Micelle
Leah Pandiscia, PhD
July 28, 2017
Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols… Continue reading Chemical Constituents Isolated from Bletilla striataand Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells
Leah Pandiscia, PhD
July 28, 2017
A new marine ecdysteroid with an α-hydroxy group attaching at C-4 instead of attaching at C-2 and C-3, named palythone… Continue reading Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki
Leah Pandiscia, PhD
July 28, 2017
The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including… Continue reading Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Leah Pandiscia, PhD
July 28, 2017