Leah Pandiscia, PhD
March 24, 2020
L-Homocysteine (Hcy) is a non-proteinogenic α-amino acid synthesized from dietary methionine. In healthy humans, high Hcy levels are a risk… Continue reading S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset
Leah Pandiscia, PhD
March 24, 2020
Curcumin, a primary active element of turmeric, has potent antioxidant and anti-inflammatory activity, but its low bioavailability is a major… Continue reading Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis
Leah Pandiscia, PhD
March 24, 2020
In this study, room temperature ferromagnetism was induced in diamagnetic BaSnO3 ceramic through light doping with non-magnetic elements composed of Tl,… Continue reading Role of non-magnetic dopants on the room temperature ferromagnetism and optical properties of BaSnO3 perovskite
Leah Pandiscia, PhD
March 24, 2020
Riboswitches are a class of non-protein–coding RNAs that directly sense cellular metabolites to regulate gene expression. They are model systems… Continue reading Nucleobase mutants of a bacterial preQ1-II riboswitch that uncouple metabolite sensing from gene regulation
Leah Pandiscia, PhD
March 24, 2020
Multi-spanning membrane proteins usually require solubilization to allow proper purification and characterization, which generally impairs their structural and functional integrity.… Continue reading Membrane matters: The impact of a nanodisc-bilayer or a detergent microenvironment on the properties of two eubacterial rhodopsins
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
In this study, a three-armed dendritic molecule, 1,3,5-tris(10-(4-(2,6-diphenylpyrimidin-4-yl)phenyl)-9,9-diphenyl-9,10-dihydroacridin-2-yl)benzene (3PDPAc), was successfully synthesized and utilized as a blue dopant and its… Continue reading Blue-emitting dendritic molecule with dual functionality as host and dopant for solution-processed white OLEDs with red-emitting material
Leah Pandiscia, PhD
March 24, 2020
This study presents the preparation, characterization, and properties of a new composite containing cerium oxide nanoparticles and a conjugated polymer.… Continue reading Interface Interactions in Conjugated Polymer Composite with Metal Oxide Nanoparticles
Leah Pandiscia, PhD
March 24, 2020
Using biomass materials as exfoliating agents to produce graphene is a promising strategy due to their biocompatibility, reproducibility and sustainability.… Continue reading One-pot preparation of zwitterionic graphene nanosheets with exceptional redispersibility and its application in pickering emulsions
Leah Pandiscia, PhD
March 24, 2020
Piperlongumine (PPL) has presented a variety of important pharmacological activities. In recent pharmacokinetics studies in rats, this molecule reached 76.39%… Continue reading Details of the cooperative binding of piperlongumine with rat serum albumin obtained by spectroscopic and computational analyses
Leah Pandiscia, PhD
March 24, 2020
Entamoeba histolytica infection is highly prevalent in developing countries across the globe. The ATP synthesis in this pathogen is solely dependent… Continue reading Biochemical and biophysical characterization of the smallest pyruvate kinase from Entamoeba histolytica
Leah Pandiscia, PhD
March 24, 2020
The Escherichia coli SecA ATPase motor protein is essential for secretion of proteins through the SecYEG translocon into the periplasmic space. Its… Continue reading Binding of SecA ATPase monomers and dimers to lipid vesicles
Leah Pandiscia, PhD
March 24, 2020
DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in… Continue reading Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex… Continue reading Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides
Leah Pandiscia, PhD
March 24, 2020
Protein-based nanoassemblies can encapsulate hydrophobic compounds into their hydrophobic region and effectively improve their aqueous solubility and stability. However, hydrolyzed… Continue reading The construction of enzymolyzed α-lactalbumin based micellar nanoassemblies for encapsulating various kinds of hydrophobic bioactive compounds
Leah Pandiscia, PhD
March 24, 2020
A new lignan, thoreliin A (1), and a new bisnorlignan, thoreliin B (2), were isolated from a MeOH extract of… Continue reading Anti-HIV-1 activities of constituents from the rhizomes of Boesenbergia thorelii
Leah Pandiscia, PhD
June 29, 2020