KnowledgeBase Articles Archive

Copper(II)-Binding Induces a Unique Polyproline Type II Helical Structure within the Ion-Binding Segment in the Intrinsically Disordered F-Domain of Ecdysteroid Receptor from Aedes aegypti

2019 / Inorganic Chemistry

Reproduction of the dominant vector of Zika and dengue diseases, Aedes aegypti mosquito, is controlled by an active heterodimer complex composed of… Continue reading Copper(II)-Binding Induces a Unique Polyproline Type II Helical Structure within the Ion-Binding Segment in the Intrinsically Disordered F-Domain of Ecdysteroid Receptor from Aedes aegypti

Ligand-Induced G-Quadruplex Polymorphism: A DNA Nanodevice for Label-Free Aptasensor Platforms

2019 / JACS

G-Quadruplexes (GQs) serve as popular recognition elements for DNA aptasensors and are incorporated into a DNA nanodevice capable of controlled… Continue reading Ligand-Induced G-Quadruplex Polymorphism: A DNA Nanodevice for Label-Free Aptasensor Platforms

Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation

2019 / Journal of Biological Chemistry

Structural changes of globular proteins and their resultant amyloid aggregation have been associated with various human diseases, such as lysozyme… Continue reading Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation

Pyrimidine Nucleosides from Streptomyces sp. SSA28

2019 / Journal of Natural Products

Eleven new pyrimidine nucleosides (1–11) and 12 known analogues (12–23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new… Continue reading Pyrimidine Nucleosides from Streptomyces sp. SSA28

Thermodynamics, molecular modelling and denaturation studies on exploring the binding mechanism of tetramethylpyrazine with human serum albumin

2020 / The Journal of Chemical Thermodynamics

Tetramethylpyrazine (TMPZ), a Chinese herb effectively used for cardiovascular disorders. The present study reports in vitro interaction studies of TMPZ with human… Continue reading Thermodynamics, molecular modelling and denaturation studies on exploring the binding mechanism of tetramethylpyrazine with human serum albumin

Virgicin, a novel lanthipeptide from Virgibacillus sp. strain AK90 exhibits inhibitory activity against Gram-positive bacteria

2019 / World Journal of Microbiology and Biotechnology

There is a significant increase in the discovery of new antimicrobial compounds in recent past to combat drug resistant pathogens.… Continue reading Virgicin, a novel lanthipeptide from Virgibacillus sp. strain AK90 exhibits inhibitory activity against Gram-positive bacteria

Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage

2020 / Scientific Reports

A chemical study of the EtOAc extract of Nemania bipapillata (AT-05), an endophytic fungus isolated from the marine red alga Asparagopsis taxiformis – Falkenbergia stage, led… Continue reading Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage

Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

2019 / Scientific Reports

Cholera is a life-threatening diarrhoeal disease caused by the human pathogen Vibrio cholerae. Infection occurs after ingestion of the bacteria, which… Continue reading Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

Reduced Renal Colonization and Enhanced Protection by Leptospiral Factor H Binding Proteins as a Multisubunit Vaccine Against Leptospirosis in Hamsters

2019 / Vaccines

Subunit vaccines conferring complete protection against leptospirosis are not currently available. The interactions of factor H binding proteins (FHBPs) on… Continue reading Reduced Renal Colonization and Enhanced Protection by Leptospiral Factor H Binding Proteins as a Multisubunit Vaccine Against Leptospirosis in Hamsters

Fluorescein-Stabilized i-Motif DNA and Its Unfolding Leading to a Stronger Adsorption Affinity

2019 / Langmuir

Several previous studies have indicated that polydeoxycytidine (poly-C) DNA has an anomalously high affinity for different types of surfaces. It… Continue reading Fluorescein-Stabilized i-Motif DNA and Its Unfolding Leading to a Stronger Adsorption Affinity

Thermally Evaporated Organic/Ag/Organic Multilayer Transparent Conducting Electrode for Flexible Organic Light‐Emitting Diodes

2019 / Advanced Electronic Materials

This paper reports an efficient, thermally stable, and high‐performance flexible multilayer transparent conducting electrode (TCE) by sandwiching an ultrathin Ag… Continue reading Thermally Evaporated Organic/Ag/Organic Multilayer Transparent Conducting Electrode for Flexible Organic Light‐Emitting Diodes

Structural Dynamics of the Paddle Motif Loop in the Activated Conformation of KvAP Voltage Sensor

2019 / Biophysical Journal

Voltage-dependent potassium (Kv) channels play a fundamental role in neuronal and cardiac excitability and are potential therapeutic targets. They assemble… Continue reading Structural Dynamics of the Paddle Motif Loop in the Activated Conformation of KvAP Voltage Sensor

Highly reliable and transparent Al doped Ag cathode fabricated using thermal evaporation for transparent OLED applications

2020 / Organic Electronics

Here, we report a highly reliable and transparent cathode (TC) for transparent organic light emitting diode (TOLED) applications. The cathode… Continue reading Highly reliable and transparent Al doped Ag cathode fabricated using thermal evaporation for transparent OLED applications

Self-association of type I collagen directed by thymoquinone through alteration of molecular forces

2019 / International Journal of Biological Macromolecules

Type I collagen is a vital structural component of the extracellular matrix providing the connective tissues with biomechanical support. One… Continue reading Self-association of type I collagen directed by thymoquinone through alteration of molecular forces

Copper complexes of synthetic peptides mimicking neurotrophin-3 enhance neurite outgrowth and CREB phosphorylation

2019 / Metallomics

In this work we report on the synthesis and physiochemical/biological characterization of a peptide encompassing the first thirteen residues of… Continue reading Copper complexes of synthetic peptides mimicking neurotrophin-3 enhance neurite outgrowth and CREB phosphorylation

Multiple spectroscopic and theoretical investigation of meso-tetra-(4-pyridyl)porphyrin‑ruthenium(II) complexes in HSA-binding studies. Effect of Zn(II) in protein binding

2020 / Journal of Molecular Liquids

The present work reports the interaction between human serum albumin (HSA) – the main bio-distributor of exogenous and endogenous compounds… Continue reading Multiple spectroscopic and theoretical investigation of meso-tetra-(4-pyridyl)porphyrin‑ruthenium(II) complexes in HSA-binding studies. Effect of Zn(II) in protein binding

Structural characterization of transfection nanosystems based on tricationic surfactants and short double stranded oligonucleotides

2019 / Biochemical and Biophysical Research Communications

For several years cationic surfactants have been the subjects of extensive studies as potential transgene carriers to be used in… Continue reading Structural characterization of transfection nanosystems based on tricationic surfactants and short double stranded oligonucleotides

Characterization of an alkali-stable xyloglucanase/mixed-linkage β-glucanase Pgl5A from Paenibacillus sp. S09

2019 / International Journal of Biological Macromolecules

Xyloglucans and mixed-linkage β-glucans are the major components of hemicelluloses in lignocellulosic biomass. In this study, a novel β-1,4-glucanase Pgl5A… Continue reading Characterization of an alkali-stable xyloglucanase/mixed-linkage β-glucanase Pgl5A from Paenibacillus sp. S09

Self‐Assembly of Ferrocene Peptides: A Nonheme Strategy to Construct a Peroxidase Mimic

2019 / Advanced Materials Interfaces

In this study, a novel nonheme strategy is developed to construct a peroxidase (POD) mimic through the self‐assembly of ferrocene‐derived… Continue reading Self‐Assembly of Ferrocene Peptides: A Nonheme Strategy to Construct a Peroxidase Mimic

Enhanced paracellular delivery of vaccine by hydrogel microparticles-mediated reversible tight junction opening for effective oral immunization

2019 / Journal of Controlled Release

The current conventional injectable vaccines face several drawbacks such as inconvenience and ineffectiveness in mucosal immunization. Therefore, the current development… Continue reading Enhanced paracellular delivery of vaccine by hydrogel microparticles-mediated reversible tight junction opening for effective oral immunization

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